Journal of Sports Science and Medicine
Journal of Sports Science and Medicine
Journal homepage
ISSN: 1303 - 2968   
Ios-APP Journal of Sports Science and Medicine
Androit-APP Journal of Sports Science and Medicine
Views
7666
Download
912
from September 2014
 
Citations in
ScholarGoogle
©Journal of Sports Science and Medicine (2007) 06, 434 - 440

Research article
IGF-1 Gene Expression in Rat Colonic Mucosa After Different Exercise Volumes
Katja Buehlmeyer1, , Frank Doering2, Hannelore Daniel3, Anatoli Petridou4, Vassilis Mougios4, Thorsten Schulz1, Horst Michna1
Author Information
1 Institute of Public Health Research, Technical University Munich, Munich, Germany
2 Molecular Nutrition, Christian-Albrechts-University of Kiel, Kiel, Germany
3 Molecular Nutrition, Technical University Munich, Freising, Weihenstephan, Germany
4 Department of Physical Education and Sport Science, Aristoteles University of Thessaloniki, Thessaloniki, Greece

Katja Buehlmeyer
✉ Technical University Munich, Institute of Public Health Research, Connollystreet 32, 80809 Munich, Germany
Email: katjabuehlmeyer@gmx.net
Publish Date
Received: 12-03-2007
Accepted: 27-06-2007
Published (online): 01-12-2007
How to Cite
  Full Text
   PDF
 
 
ABSTRACT

The evidence is increasing for a close link between the insulin/insulin-like growth factor (IGF) system and colon cancer prevention by physical exercise. To reveal exercise-induced alterations in colon mucosa, gene expression of IGF-1 and related genes and serum IGF-1 were investigated. Twenty male Wistar rats performed a 12 week voluntary exercise program. Nine rats served as the control group. Gene expression of IGF-1, IGF-1 receptor (IGF-1R) and IGF-binding protein 3 (IGF-BP3) were quantified by real-time RT-PCR. Circulating IGF-1 was analyzed exercise volume-dependent. Based on 3 distinguished groups with low (L-EX, <2629 m·night-1), medium (M-EX, 3003-7458 m·night-1) and high exercise volume (H-EX, >8314 m·night-1), we observed lower serum IGF-1 levels (P < 0.05) in all exercise groups as compared to the control group and IGF-1 levels declined proportional to the increase in exercise volume. A significant (p < 0.05) positive correlation was found between IGF-1 concentration and body mass (r = 0.50) and a significant negative correlation exists between body mass and exercise volume (r = -0.50). Significant differences in colonic mRNA levels of IGF-1, IGF-1R and IGF-BP3 could not be observed. Based on our data we propose that the exercise as well as the body mass reduction leads to a decrease in circulating IGF-1 and this might represent a prime link to colon cancer prevention.
Key words: Cancer prevention, IGF-1R, IGF-BP3, real-time RT PCR, physical exercise


           Key Points
  • There were significantly lower serum IGF-1 levels in all exercise groups as compared to the control group.
  • GF-1 levels declined proportional to the increase in exercise volume.
  • A significant positive correlation was found between IGF-1 concentration and body mass and a significant negative correlation was found between body mass and exercise volume.
  • Significant differences in colonic mRNA levels of IGF-1, IGF-1R and IGF-BP3 could not be observed.
 
 
Home Issues About Authors
Contact Current Editorial board Authors instructions
Email alerts In Press Mission For Reviewers
Archive Scope
Supplements Statistics
Most Read Articles
  Most Cited Articles
 
  
 
JSSM | Copyright 2001-2024 | All rights reserved. | LEGAL NOTICES | Publisher

It is forbidden the total or partial reproduction of this web site and the published materials, the treatment of its database, any kind of transition and for any means, either electronic, mechanic or other methods, without the previous written permission of the JSSM.

This work is licensed under a Creative Commons License Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.